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Cultivating Genetic Testing Expertise: How to Improve Your Clinical Competency in the ABMGG LGG Fellowship

Based on the ACGME-approved ABMGG LGG fellowship training purpose and milestone, the clinical competency is one of the most important competency the fellow should be trained during the fellowship training period. However, it is not clear how to improve the clinical competency. What should you do to improve your clinical competency?



The ABMGG Clinical Laboratory Genetics and Genomics (LGG) fellowship equips you with the knowledge and skills to excel in this dynamic field. But beyond the theoretical foundation, lies the crucial development of clinical competency – the ability to translate knowledge into tangible improvements in patient care. To excel in this role and deliver optimal patient care, it's essential to continually enhance your clinical competency across various aspects of laboratory testing and result interpretation.


This post explores how to sharpen your skills across the entire testing process, from pre-analytic to post-analytic phases, during your LGG fellowship


1. Pre-Analytical Skills: Ensuring Sample Integrity and Adequate Patient Information


Pre-analytic steps, often unseen, are vital for accurate results. Pre-analytical skills are crucial for ensuring the integrity of samples and accurate test results. Here's how to refine your skills:


  • Specimen Acquisition and Handling: Read assay validation summary in the lab and familiarize yourself with proper sample collection techniques and specimen handling protocols. Master proper collection techniques, understand the impact of pre-analytical variables (e.g., the time between sample collection and sample process), any variables or conditions for suboptimal samples, sample rejection QC parameter and communicate with referring physicians about appropriate specimen collection. If there are no established QC parameters, implement quality control measures to monitor pre-analytical variables and minimize the risk of pre-analytical errors.

  • Test Selection and Ordering: Gain a deep understanding of test indications, limitations, and alternative testing options. Advocate for appropriate test selection based on clinical context. Verify patient information and sample labeling accuracy to prevent errors. Communicate effectively with healthcare providers to obtain comprehensive clinical histories and relevant patient information, which are vital for accurate test interpretation.



2. Analytical Skills: Performing Accurate and Reliable Laboratory Testing


Analytical skills are fundamental for conducting precise and reliable laboratory tests. To enhance your analytical abilities:


  • Technical Proficiency:  Master laboratory techniques and methodologies used for genetic testing, such as PCR, sequencing, and microarray analysis. Adhere to standardized protocols and quality assurance practices to minimize analytical variability. Participate in proficiency testing programs and continuing education opportunities to stay updated on advances in laboratory technology and best practices in genetic testing. Participate in method development and validation processes to understand the nuances of each test.

  • Troubleshooting and Problem-Solving: Maintain proficiency in instrument operation, calibration, and troubleshooting to ensure accurate test results. Develop a systematic approach to troubleshoot technical issues and identify potential sources of error. Learn from experienced lab personnel and actively participate in quality control procedures.


3. Post-Analytical Skills: Test Result Analysis, Interpretation, and Result Reporting


Post-analytic steps translate raw data into meaningful results that impact patient care. and effective communication of findings to healthcare providers. To refine your post-analytical skills:


  • Data Analysis and Interpretation: Develop proficiency in interpreting genetic test results and correlating them with clinical findings to provide accurate diagnostic assessments. Utilize bioinformatics tools and databases to aid in variant interpretation and classification. Understand and describe the test limitations.

  • Report Writing and Communication: Craft clear, concise, and informative clinical reports that effectively communicate results and their implications to referring physicians. Learn to tailor reports to the specific needs of the requesting clinician. Collaborate with multidisciplinary teams, including genetic counselors and clinicians, to ensure comprehensive patient management.


4. Continuous Improvement: Continuous Learning, Seeking Feedback and Collaboration


Continuous improvement is key to advancing your clinical competency and patient care skills throughout the fellowship. To foster ongoing growth:


  • Embrace Continuous Learning: The field of LGG is constantly evolving. Stay updated on the latest methodologies, guidelines, and advancements through participation in conferences, workshops, and independent study. More specifically, engage in regular case discussions, journal clubs, and educational seminars to enhance your knowledge base and clinical reasoning skills. Also, pursue additional training opportunities, such as workshops or conferences, to expand your expertise in specific areas of clinical genetics. Embrace a mindset of lifelong learning and professional development, remaining open to new challenges and opportunities for growth.

  • Seek Mentorship: Forge strong relationships with experienced lab personnel and faculty members. Seek guidance in developing your skills and navigating any challenges you encounter. Seek feedback from mentors, preceptors, and colleagues to identify areas for improvement and tailor your learning objectives accordingly.

  • Embrace Collaboration: The LGG field thrives on collaboration. Actively participate in case conference, tumor/leukemia board meeting, share your expertise with colleagues, and actively seek opportunities to learn from other fellows and lab personnel.



Endless effort to improve clinical competency during the LGG fellowship training


By focusing on enhancing pre-analytical, analytical, and post-analytical skills, as well as embracing continuous improvement during your LGG fellowship, you'll develop a comprehensive skillset that allows you to excel in all phases of clinical laboratory testing. Remember, continuous learning, a commitment to accuracy, and effective communication are all essential for delivering the highest quality of patient care in the field of Laboratory Genetics and Genomics.

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